5EXA

Small-molecule stabilization of the 14-3-3/Gab2 PPI interface

Summary for 5EXA

Entry DOI	10.2210/pdb5exa/pdb
Related	3CU8 4FJ3 4IHL 4N7Y
Descriptor	14-3-3 protein zeta/delta, GRB2-associated-binding protein 2, Fusicoccin A-THF derivative, ... (6 entities in total)
Functional Keywords	14-3-3, gab2, protein, diphosphorylation, signaling protein
Biological source	Homo sapiens (Human) More
Total number of polymer chains	4
Total formula weight	56736.40
Authors	Bier, D.,Ottmann, C. (deposition date: 2015-11-23, release date: 2016-05-04, Last modification date: 2018-12-19)
Primary citation	Bier, D.,Bartel, M.,Sies, K.,Halbach, S.,Higuchi, Y.,Haranosono, Y.,Brummer, T.,Kato, N.,Ottmann, C. Small-Molecule Stabilization of the 14-3-3/Gab2 Protein-Protein Interaction (PPI) Interface. Chemmedchem, 11:911-918, 2016 Cited by PubMed: 26644359 DOI: 10.1002/cmdc.201500484 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (1.95 Å)

Structure validation