5EV6
Crystal structure of the native, di-zinc metallo-beta-lactamase IMP-1
Summary for 5EV6
| Entry DOI | 10.2210/pdb5ev6/pdb |
| Descriptor | Beta-lactamase IMP-1, ZINC ION, 1,2-ETHANEDIOL, ... (5 entities in total) |
| Functional Keywords | inhibitor, carbapenemase, antibiotic resistance, hydrolase |
| Biological source | Serratia marcescens |
| Cellular location | Periplasm : P52699 |
| Total number of polymer chains | 4 |
| Total formula weight | 101909.83 |
| Authors | Spencer, J.,Hinchliffe, P. (deposition date: 2015-11-19, release date: 2016-06-01, Last modification date: 2024-01-10) |
| Primary citation | Hinchliffe, P.,Gonzalez, M.M.,Mojica, M.F.,Gonzalez, J.M.,Castillo, V.,Saiz, C.,Kosmopoulou, M.,Tooke, C.L.,Llarrull, L.I.,Mahler, G.,Bonomo, R.A.,Vila, A.J.,Spencer, J. Cross-class metallo-beta-lactamase inhibition by bisthiazolidines reveals multiple binding modes. Proc.Natl.Acad.Sci.USA, 113:E3745-E3754, 2016 Cited by PubMed: 27303030DOI: 10.1073/pnas.1601368113 PDB entries with the same primary citation |
| Experimental method | X-RAY DIFFRACTION (1.984 Å) |
Structure validation
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