5EQB

Crystal structure of lanosterol 14-alpha demethylase with intact transmembrane domain bound to itraconazole

「4K0F」から置き換えられました

5EQB の概要

• エントリーDOI: 10.2210/pdb5eqb/pdb
• 分子名称: Lanosterol 14-alpha demethylase, PROTOPORPHYRIN IX CONTAINING FE, 2-[(2R)-butan-2-yl]-4-{4-[4-(4-{[(2R,4S)-2-(2,4-dichlorophenyl)-2-(1H-1,2,4-triazol-1-ylmethyl)-1,3-dioxolan-4-yl]methoxy}phenyl)piperazin-1-yl]phenyl}-2,4-dihydro-3H-1,2,4-triazol-3-one, ... (4 entities in total)
• 機能のキーワード: sterol antifungal membrane cytochrome, structural genomics, psi-2, protein structure initiative, center for structures of membrane proteins, csmp, oxidoreductase-oxidoreductase inhibitor complex, oxidoreductase/oxidoreductase inhibitor
• 由来する生物種: Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
• 細胞内の位置: Membrane; Single-pass membrane protein: P10614
• タンパク質・核酸の鎖数: 1
• 化学式量合計: 63207.33

構造登録者

Monk, B.C.,Tomasiak, T.M.,Keniya, M.V.,Huschmann, F.U.,Tyndall, J.D.A.,O'Connell III, J.D.,Cannon, R.D.,Finer-Morre, J.,Stroud, R.M.,Center for Structures of Membrane Proteins (CSMP) (登録日: 2015-11-12, 公開日: 2016-01-13, 最終更新日: 2024-03-06)

• 主引用文献: Monk, B.C.,Tomasiak, T.M.,Keniya, M.V.,Huschmann, F.U.,Tyndall, J.D.,O'Connell, J.D.,Cannon, R.D.,McDonald, J.G.,Rodriguez, A.,Finer-Moore, J.S.,Stroud, R.M.; Architecture of a single membrane spanning cytochrome P450 suggests constraints that orient the catalytic domain relative to a bilayer.; Proc.Natl.Acad.Sci.USA, 111:3865-3870, 2014; PubMed: 24613931; DOI: 10.1073/pnas.1324245111

実験手法

X-RAY DIFFRACTION (2.19 Å)