5EP7

Crystal structure of the bromodomain of human CREBBP in complex with UN32

Summary for 5EP7

Entry DOI	10.2210/pdb5ep7/pdb
Descriptor	CREB-binding protein, 3-[(1-methyl-6-oxidanylidene-pyridin-3-yl)carbonylamino]benzoic acid (3 entities in total)
Functional Keywords	transcription, inhibitor, transferase
Biological source	Homo sapiens (Human)
Total number of polymer chains	1
Total formula weight	14495.60
Authors	Dong, J.,Caflisch, A. (deposition date: 2015-11-11, release date: 2016-11-23, Last modification date: 2018-10-10)
Primary citation	Zhu, J.,Dong, J.,Batiste, L.,Unzue, A.,Dolbois, A.,Pascanu, V.,Sledz, P.,Nevado, C.,Caflisch, A. Binding Motifs in the CBP Bromodomain: An Analysis of 20 Crystal Structures of Complexes with Small Molecules. ACS Med Chem Lett, 9:929-934, 2018 Cited by PubMed: 30258543 DOI: 10.1021/acsmedchemlett.8b00286 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (1.198 Å)

Structure validation