5ENH

Crystal structure of the second bromodomain of Pleckstrin homology domain interacting protein (PHIP) in complex with compound-12 N11528 (SGC - Diamond I04-1 fragment screening)

5ENH の概要

• エントリーDOI: 10.2210/pdb5enh/pdb
• 分子名称: PH-interacting protein, ~{N}-[(2,6-dimethoxyphenyl)methyl]ethanamide (3 entities in total)
• 機能のキーワード: bromodomain, phip, crystallographic fragment screen, structural genomics, structural genomics consortium, sgc, transcription, signaling protein
• 由来する生物種: Homo sapiens (Human)
• タンパク質・核酸の鎖数: 1
• 化学式量合計: 15803.90

構造登録者

Krojer, T.,Talon, R.,Collins, P.,Bradley, A.,Cox, O.,Szykowska, A.,Burgess-Brown, N.,Brennan, P.,Bountra, C.,Arrowsmith, C.H.,Edwards, A.,von Delft, F.,Structural Genomics Consortium (SGC) (登録日: 2015-11-09, 公開日: 2016-04-27, 最終更新日: 2024-01-10)

• 主引用文献: Cox, O.B.,Krojer, T.,Collins, P.,Monteiro, O.,Talon, R.,Bradley, A.,Fedorov, O.,Amin, J.,Marsden, B.D.,Spencer, J.,von Delft, F.,Brennan, P.E.; A poised fragment library enables rapid synthetic expansion yielding the first reported inhibitors of PHIP(2), an atypical bromodomain.; Chem Sci, 7:2322-2330, 2016; PubMed: 29910922; DOI: 10.1039/c5sc03115j

実験手法

X-RAY DIFFRACTION (1.95 Å)