5ENG
Crystal structure of the bromodomain of human CREBBP in complex with UP39
Summary for 5ENG
Entry DOI | 10.2210/pdb5eng/pdb |
Descriptor | CREB-binding protein, methyl 2-[2-(3,5-dihydro-2~{H}-pyrazin-4-yl)ethoxy]-5-[(5-ethanoyl-2-ethoxy-phenyl)carbamoyl]benzoate (3 entities in total) |
Functional Keywords | transcription, inhibitor, transferase |
Biological source | Homo sapiens (Human) |
Total number of polymer chains | 1 |
Total formula weight | 14690.86 |
Authors | Dong, J.,Caflisch, A. (deposition date: 2015-11-09, release date: 2016-11-23, Last modification date: 2024-01-10) |
Primary citation | Zhu, J.,Dong, J.,Batiste, L.,Unzue, A.,Dolbois, A.,Pascanu, V.,Sledz, P.,Nevado, C.,Caflisch, A. Binding Motifs in the CBP Bromodomain: An Analysis of 20 Crystal Structures of Complexes with Small Molecules. ACS Med Chem Lett, 9:929-934, 2018 Cited by PubMed: 30258543DOI: 10.1021/acsmedchemlett.8b00286 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (1.3 Å) |
Structure validation
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