5ENF
Crystal structure of the second bromodomain of Pleckstrin homology domain interacting protein (PHIP) in complex with fragment-4 N10142 (SGC - Diamond I04-1 fragment screening)
Summary for 5ENF
| Entry DOI | 10.2210/pdb5enf/pdb |
| Descriptor | PH-interacting protein, 1,2-ETHANEDIOL, 5-azanyl-2-(2-methylpropyl)-1,3-oxazole-4-carbonitrile, ... (4 entities in total) |
| Functional Keywords | bromodomain, phip, crystallographic fragment screen, transcription, structural genomics, structural genomics consortium, sgc, signaling protein |
| Biological source | Homo sapiens (Human) |
| Total number of polymer chains | 1 |
| Total formula weight | 15883.99 |
| Authors | Krojer, T.,Talon, R.,Collins, P.,Bradley, A.,Cox, O.,Amin, J.,Szykowska, A.,Burgess-Brown, N.,Spencer, J.,Brennan, P.,Bountra, C.,Arrowsmith, C.H.,Edwards, A.,von Delft, F.,Structural Genomics Consortium (SGC) (deposition date: 2015-11-09, release date: 2016-04-27, Last modification date: 2024-01-10) |
| Primary citation | Cox, O.B.,Krojer, T.,Collins, P.,Monteiro, O.,Talon, R.,Bradley, A.,Fedorov, O.,Amin, J.,Marsden, B.D.,Spencer, J.,von Delft, F.,Brennan, P.E. A poised fragment library enables rapid synthetic expansion yielding the first reported inhibitors of PHIP(2), an atypical bromodomain. Chem Sci, 7:2322-2330, 2016 Cited by PubMed: 29910922DOI: 10.1039/c5sc03115j PDB entries with the same primary citation |
| Experimental method | X-RAY DIFFRACTION (1.37 Å) |
Structure validation
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