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5ENE

Crystal structure of the second bromodomain of Pleckstrin homology domain interacting protein (PHIP) in complex with 5-Amino-2-benzyl-1,3-oxazole-4-carbonitrile (SGC - Diamond I04-1 fragment screening)

5ENE の概要
エントリーDOI10.2210/pdb5ene/pdb
分子名称PH-interacting protein, 5-azanyl-2-(phenylmethyl)-1,3-oxazole-4-carbonitrile (3 entities in total)
機能のキーワードbromodomain, phip, crystallographic fragment screen, transcription, structural genomics, structural genomics consortium, sgc, signaling protein
由来する生物種Homo sapiens (Human)
タンパク質・核酸の鎖数1
化学式量合計15793.87
構造登録者
主引用文献Cox, O.B.,Krojer, T.,Collins, P.,Monteiro, O.,Talon, R.,Bradley, A.,Fedorov, O.,Amin, J.,Marsden, B.D.,Spencer, J.,von Delft, F.,Brennan, P.E.
A poised fragment library enables rapid synthetic expansion yielding the first reported inhibitors of PHIP(2), an atypical bromodomain.
Chem Sci, 7:2322-2330, 2016
Cited by
PubMed: 29910922
DOI: 10.1039/c5sc03115j
主引用文献が同じPDBエントリー
実験手法
X-RAY DIFFRACTION (1.49 Å)
構造検証レポート
Validation report summary of 5ene
検証レポート(詳細版)ダウンロードをダウンロード

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件を2024-03-27に公開中

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