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5EIS

FIRST DOMAIN OF HUMAN BROMODOMAIN BRD4 IN COMPLEX WITH INHIBITOR 3-(4-Chlorobenzyl)-7-ethyl-3,7-dihydropurine-2,6-dione

Summary for 5EIS
Entry DOI10.2210/pdb5eis/pdb
DescriptorBromodomain-containing protein 4, 3-[(4-chlorophenyl)methyl]-7-ethyl-purine-2,6-dione, 1,2-ETHANEDIOL, ... (4 entities in total)
Functional Keywordsinhibitor, histone, epigenetic reader, bromodomain, brd4_bd1, transcription
Biological sourceHomo sapiens (Human)
More
Cellular locationNucleus: O60885
Total number of polymer chains1
Total formula weight15528.25
Authors
Raux, B.,Rebuffet, E.,Betzi, S.,Morelli, X. (deposition date: 2015-10-30, release date: 2016-01-20, Last modification date: 2024-01-10)
Primary citationRaux, B.,Voitovich, Y.,Derviaux, C.,Lugari, A.,Rebuffet, E.,Milhas, S.,Priet, S.,Roux, T.,Trinquet, E.,Guillemot, J.C.,Knapp, S.,Brunel, J.M.,Fedorov, A.Y.,Collette, Y.,Roche, P.,Betzi, S.,Combes, S.,Morelli, X.
Exploring Selective Inhibition of the First Bromodomain of the Human Bromodomain and Extra-terminal Domain (BET) Proteins.
J.Med.Chem., 59:1634-1641, 2016
Cited by
PubMed: 26735842
DOI: 10.1021/acs.jmedchem.5b01708
PDB entries with the same primary citation
Experimental method
X-RAY DIFFRACTION (1.6 Å)
Structure validation

222624

數據於2024-07-17公開中

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