5EHX
Crystal structure of MSF-aged Torpedo californica Acetylcholinesterase
Summary for 5EHX
| Entry DOI | 10.2210/pdb5ehx/pdb |
| Descriptor | Acetylcholinesterase, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose, ... (6 entities in total) |
| Functional Keywords | alpha beta hydrolase, irreversible inhibitor, hydrolase |
| Biological source | Torpedo californica (Pacific electric ray) |
| Cellular location | Isoform H: Cell membrane; Lipid-anchor, GPI- anchor. Isoform T: Cell membrane; Peripheral membrane protein: P04058 |
| Total number of polymer chains | 1 |
| Total formula weight | 61423.23 |
| Authors | Pesaresi, A.,Lamba, D. (deposition date: 2015-10-29, release date: 2016-11-09, Last modification date: 2024-09-25) |
| Primary citation | Stojan, J.,Pesaresi, A.,Meden, A.,Lamba, D. Disentangling the formation, mechanism, and evolvement of the covalent methanesulfonyl fluoride acetylcholinesterase adduct: Insights into an aged-like inactive complex susceptible to reactivation by a combination of nucleophiles. Protein Sci., 33:e4977-e4977, 2024 Cited by PubMed: 38591646DOI: 10.1002/pro.4977 PDB entries with the same primary citation |
| Experimental method | X-RAY DIFFRACTION (2.1 Å) |
Structure validation
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