5EGM

Development of a novel tricyclic class of potent and selective FIXa inhibitors

Summary for 5EGM

• Entry DOI: 10.2210/pdb5egm/pdb
• Descriptor: Coagulation factor IX, SODIUM ION, 2-[N-CYCLOHEXYLAMINO]ETHANE SULFONIC ACID, ... (6 entities in total)
• Functional Keywords: serine proteinase, blood coagulation, coagulation factor, hydrolase-2 hydrolase inhibitor complex, hydrolase-hydrolase inhibitor complex, hydrolase/hydrolase inhibitor
• Biological source: Homo sapiens (Human); More
• Cellular location: Secreted : P00740 P00740
• Total number of polymer chains: 2
• Total formula weight: 33726.81

Authors

Meng, D.,Andre, P.,Bateman, T.J.,Berger, R.,Chen, Y.,Desai, K.,Dewnani, S.,Ellsworth, K.,Feng, D.,Geissler, W.M.,Guo, L.,Hruza, A.,Jian, T.,Li, H.,Parker, D.L.,Reichert, P.,Sherer, E.C.,Smith, C.J.,Sonatore, L.M.,Tschirret-Guth, R.,Wu, J.,Xu, J.,Zhang, T.,Campeau, L.,Orr, R.,Poirier, M.,McCabe-Dunn, j.,Araki, K.,Nishimura, T.,Sakurada, I.,Hirabayashi, T.,Wood, H.B. (deposition date: 2015-10-27, release date: 2015-11-18, Last modification date: 2023-09-27)

• Primary citation: Meng, D.,Andre, P.,Bateman, T.J.,Berger, R.,Chen, Y.H.,Desai, K.,Dewnani, S.,Ellsworth, K.,Feng, D.,Geissler, W.M.,Guo, L.,Hruza, A.,Jian, T.,Li, H.,Metzger, J.,Parker, D.L.,Reichert, P.,Sherer, E.C.,Smith, C.J.,Sonatore, L.M.,Tschirret-Guth, R.,Wu, J.,Xu, J.,Zhang, T.,Campeau, L.C.,Orr, R.,Poirier, M.,McCabe-Dunn, J.,Araki, K.,Nishimura, T.,Sakurada, I.,Hirabayashi, T.,Wood, H.B.; Development of a novel tricyclic class of potent and selective FIXa inhibitors.; Bioorg.Med.Chem.Lett., 25:5437-5443, 2015; PubMed: 26318999; DOI: 10.1016/j.bmcl.2015.07.078

Experimental method

X-RAY DIFFRACTION (1.841 Å)