5E93
Crystal Structure of Trypanosoma cruzi Dihydroorotate Dehydrogenase in Complex with Neq0071
Summary for 5E93
Entry DOI | 10.2210/pdb5e93/pdb |
Related | 5EA9 |
Descriptor | Dihydroorotate dehydrogenase (fumarate), 5-[(E)-3-(furan-2-yl)prop-2-enylidene]-1,3-diazinane-2,4,6-trione, GLYCEROL, ... (9 entities in total) |
Functional Keywords | t. cruzi, dihydroorotate dehydrogenase, covalent inhibitor, oxidoreductase-oxidoreductase inhibitor complex, oxidoreductase/oxidoreductase inhibitor |
Biological source | Trypanosoma cruzi strain CL Brener |
Total number of polymer chains | 2 |
Total formula weight | 73081.84 |
Authors | Rocha, J.R.,Inaoka, D.K.,Cheleski, J.,Shiba, T.,Harada, S.,Montanari, C.A.,Kita, K. (deposition date: 2015-10-14, release date: 2016-10-19, Last modification date: 2020-02-19) |
Primary citation | Rocha, J.R.,Cheleski, J.,Inaoka, D.K.,Avelar, L.A.,Ribeiro, J.F.R.,Wiggers, H.J.,Albuquerque, S.,Shiba, T.,Harada, S.,Kita, K.,Silva, A.B.F.,Montanari, C.A. Exploring Trypanosoma cruzi Dihydroorotate Dehydrogenase Active Site Plasticity for the Discovery of Potent and Selective Inhibitors with Trypanocidal Activity To be Published, |
Experimental method | X-RAY DIFFRACTION (1.41 Å) |
Structure validation
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