5E8R

Human HMT1 hnRNP methyltransferase-like protein 6 (S. cerevisiae)

Summary for 5E8R

Entry DOI	10.2210/pdb5e8r/pdb
Descriptor	Protein arginine N-methyltransferase 6, S-ADENOSYL-L-HOMOCYSTEINE, N-methyl-N-({4-[4-(propan-2-yloxy)phenyl]-1H-pyrrol-3-yl}methyl)ethane-1,2-diamine, ... (6 entities in total)
Functional Keywords	hrmt1l6, ms-023, structural genomics, structural genomics consortium, sgc, transferase
Biological source	Homo sapiens (Human)
Cellular location	Nucleus : Q96LA8
Total number of polymer chains	2
Total formula weight	85670.01
Authors	DONG, A.,ZENG, H.,LIU, J.,TEMPEL, W.,Seitova, A.,Hutchinson, A.,Bountra, C.,Arrowsmith, C.H.,Edwards, A.M.,JIN, J.,BROWN, P.J.,WU, H.,Structural Genomics Consortium (SGC) (deposition date: 2015-10-14, release date: 2015-12-09, Last modification date: 2024-03-06)
Primary citation	Eram, M.S.,Shen, Y.,Szewczyk, M.M.,Wu, H.,Senisterra, G.,Li, F.,Butler, K.V.,Kaniskan, H.U.,Speed, B.A.,Dela Sena, C.,Dong, A.,Zeng, H.,Schapira, M.,Brown, P.J.,Arrowsmith, C.H.,Barsyte-Lovejoy, D.,Liu, J.,Vedadi, M.,Jin, J. A Potent, Selective, and Cell-Active Inhibitor of Human Type I Protein Arginine Methyltransferases. Acs Chem.Biol., 11:772-781, 2016 Cited by PubMed: 26598975 DOI: 10.1021/acschembio.5b00839 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (2.55 Å)

Structure validation