5E8R

Human HMT1 hnRNP methyltransferase-like protein 6 (S. cerevisiae)

5E8R の概要

• エントリーDOI: 10.2210/pdb5e8r/pdb
• 分子名称: Protein arginine N-methyltransferase 6, S-ADENOSYL-L-HOMOCYSTEINE, N-methyl-N-({4-[4-(propan-2-yloxy)phenyl]-1H-pyrrol-3-yl}methyl)ethane-1,2-diamine, ... (6 entities in total)
• 機能のキーワード: hrmt1l6, ms-023, structural genomics, structural genomics consortium, sgc, transferase
• 由来する生物種: Homo sapiens (Human)
• 細胞内の位置: Nucleus : Q96LA8
• タンパク質・核酸の鎖数: 2
• 化学式量合計: 85670.01

構造登録者

DONG, A.,ZENG, H.,LIU, J.,TEMPEL, W.,Seitova, A.,Hutchinson, A.,Bountra, C.,Arrowsmith, C.H.,Edwards, A.M.,JIN, J.,BROWN, P.J.,WU, H.,Structural Genomics Consortium (SGC) (登録日: 2015-10-14, 公開日: 2015-12-09, 最終更新日: 2024-03-06)

• 主引用文献: Eram, M.S.,Shen, Y.,Szewczyk, M.M.,Wu, H.,Senisterra, G.,Li, F.,Butler, K.V.,Kaniskan, H.U.,Speed, B.A.,Dela Sena, C.,Dong, A.,Zeng, H.,Schapira, M.,Brown, P.J.,Arrowsmith, C.H.,Barsyte-Lovejoy, D.,Liu, J.,Vedadi, M.,Jin, J.; A Potent, Selective, and Cell-Active Inhibitor of Human Type I Protein Arginine Methyltransferases.; Acs Chem.Biol., 11:772-781, 2016; PubMed: 26598975; DOI: 10.1021/acschembio.5b00839

実験手法

X-RAY DIFFRACTION (2.55 Å)