5E8O

The structure of the TEIPP associated altered peptide ligand Trh4-p2ABU in complex with H-2D(b)

5E8O の概要

• エントリーDOI: 10.2210/pdb5e8o/pdb
• 分子名称: H-2 class I histocompatibility antigen, D-B alpha chain, Ceramide synthase 5, Beta-2-microglobulin, ... (4 entities in total)
• 機能のキーワード: cancer, neo-epitope, tap-deficiency, teipp, mhc-i, sulfur-pi interactions, non-canonical peptide binding, immune system
• 由来する生物種: Mus musculus (House Mouse); 詳細
• 細胞内の位置: Membrane; Single-pass type I membrane protein: P01899; Nucleus membrane ; Multi-pass membrane protein : Q9D6K9; Secreted: P01887
• タンパク質・核酸の鎖数: 6
• 化学式量合計: 89660.87

構造登録者

Hafstrand, I.,Doorduijn, E.,Duru, A.D.,Buratto, J.,Oliveira, C.C.,Sandalova, T.,van Hall, T.,Achour, A. (登録日: 2015-10-14, 公開日: 2016-02-03, 最終更新日: 2024-01-10)

• 主引用文献: Hafstrand, I.,Doorduijn, E.M.,Duru, A.D.,Buratto, J.,Oliveira, C.C.,Sandalova, T.,van Hall, T.,Achour, A.; The MHC Class I Cancer-Associated Neoepitope Trh4 Linked with Impaired Peptide Processing Induces a Unique Noncanonical TCR Conformer.; J Immunol., 196:2327-2334, 2016; PubMed: 26800871; DOI: 10.4049/jimmunol.1502249

実験手法

X-RAY DIFFRACTION (1.98 Å)