5E8F

Structure of Fully modified geranylgeranylated PDE6C Peptide in complex with PDE6D

Summary for 5E8F

• Entry DOI: 10.2210/pdb5e8f/pdb
• Descriptor: Retinal rod rhodopsin-sensitive cGMP 3',5'-cyclic phosphodiesterase subunit delta, Cone cGMP-specific 3',5'-cyclic phosphodiesterase subunit alpha', GERAN-8-YL GERAN, ... (4 entities in total)
• Functional Keywords: prenyl binding protein, immunoglobulin-like beta sandwitch fold, geranylgeranyl, hydrolase
• Biological source: Homo sapiens (Human); More
• Cellular location: Cytoplasm, cytosol : O43924; Cell membrane ; Lipid-anchor ; Cytoplasmic side : P51160
• Total number of polymer chains: 4
• Total formula weight: 36332.01

Authors

Fansa, E.K.,O'Reilly, N.J.,Ismail, S.A.,Wittinghofer, A. (deposition date: 2015-10-14, release date: 2015-11-18, Last modification date: 2024-01-10)

Primary citation

Fansa, E.K.,O'Reilly, N.J.,Ismail, S.,Wittinghofer, A.
The N- and C-terminal ends of RPGR can bind to PDE6 delta.
Embo Rep., 16:1583-1585, 2015

PubMed Abstract: This study shows that the prenylated C‐terminus of RPGR can bind to PDE6δ with high affinity, suggesting two distinct binding sites of the RPGR/PDE6δ complex. The serine residue at the −3 position relative to the prenylated cysteine seems to play a key role in defining the selectivity of PDE6δ towards ciliary prenylated cargo. [Image: see text]

PubMed: 26553937
DOI: 10.15252/embr.201541404

Experimental method

X-RAY DIFFRACTION (2.1 Å)