5E83

CRYSTAL STRUCTURE OF CARBONMONOXY HEMOGLOBIN S (LIGANDED SICKLE CELL HEMOGLOBIN) COMPLEXED WITH GBT440, CO-CRYSTALLIZATION EXPERIMENT

5E83 の概要

• エントリーDOI: 10.2210/pdb5e83/pdb
• 分子名称: Hemoglobin subunit alpha, Hemoglobin subunit beta, PROTOPORPHYRIN IX CONTAINING FE, ... (8 entities in total)
• 機能のキーワード: mutant human hemoglobin s[betae6v], r2 quaternary state, oxygen transport
• 由来する生物種: Homo sapiens (Human); 詳細
• タンパク質・核酸の鎖数: 4
• 化学式量合計: 65301.92

構造登録者

Patskovska, L.,Patskovsky, Y.,Bonanno, J.B.,Almo, S.C. (登録日: 2015-10-13, 公開日: 2016-07-20, 最終更新日: 2023-09-27)

• 主引用文献: Oksenberg, D.,Dufu, K.,Patel, M.P.,Chuang, C.,Li, Z.,Xu, Q.,Silva-Garcia, A.,Zhou, C.,Hutchaleelaha, A.,Patskovska, L.,Patskovsky, Y.,Almo, S.C.,Sinha, U.,Metcalf, B.W.,Archer, D.R.; GBT440 increases haemoglobin oxygen affinity, reduces sickling and prolongs RBC half-life in a murine model of sickle cell disease.; Br.J.Haematol., 175:141-153, 2016; PubMed: 27378309; DOI: 10.1111/bjh.14214

実験手法

X-RAY DIFFRACTION (1.8 Å)