5E73

Crystal Structure of BAZ2B bromodomain in complex with acetylindole compound UZH47

Summary for 5E73

• Entry DOI: 10.2210/pdb5e73/pdb
• Descriptor: Bromodomain adjacent to zinc finger domain protein 2B, N-(1-acetyl-1H-indol-3-yl)-N-(5-hydroxy-2-methylphenyl)acetamide (3 entities in total)
• Functional Keywords: four helical bundle, transcription
• Biological source: Homo sapiens (Human)
• Cellular location: Nucleus : Q9UIF8
• Total number of polymer chains: 1
• Total formula weight: 13853.93

Authors

Lolli, G.,Spiliotopoulos, D.,Unzue, A.,Nevado, C.,Caflisch, A. (deposition date: 2015-10-11, release date: 2015-10-28, Last modification date: 2024-01-10)

• Primary citation: Unzue, A.,Zhao, H.,Lolli, G.,Dong, J.,Zhu, J.,Zechner, M.,Dolbois, A.,Caflisch, A.,Nevado, C.; The "Gatekeeper" Residue Influences the Mode of Binding of Acetyl Indoles to Bromodomains.; J. Med. Chem., 59:3087-3097, 2016; PubMed: 26982797; DOI: 10.1021/acs.jmedchem.5b01757

Experimental method

X-RAY DIFFRACTION (1.71 Å)