5E64

Hemagglutinin-esterase-fusion protein structure of influenza D virus

5E64 の概要

• エントリーDOI: 10.2210/pdb5e64/pdb
• 関連するPDBエントリー: 5E5W 5E62 5E65 5E66
• 分子名称: Hemagglutinin-esterase, alpha-D-mannopyranose-(1-3)-[alpha-D-mannopyranose-(1-6)]alpha-D-mannopyranose-(1-6)-beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, ... (7 entities in total)
• 機能のキーワード: influenza virus, hef, surface, hydrolase
• 由来する生物種: Influenza D virus (D/swine/Oklahoma/1334/2011); 詳細
• タンパク質・核酸の鎖数: 4
• 化学式量合計: 134248.46

構造登録者

Song, H.,Qi, J.,Shi, Y.,Gao, G.F. (登録日: 2015-10-09, 公開日: 2016-03-23, 最終更新日: 2024-11-13)

主引用文献

Song, H.,Qi, J.,Khedri, Z.,Diaz, S.,Yu, H.,Chen, X.,Varki, A.,Shi, Y.,Gao, G.F.
An Open Receptor-Binding Cavity of Hemagglutinin-Esterase-Fusion Glycoprotein from Newly-Identified Influenza D Virus: Basis for Its Broad Cell Tropism
PLoS Pathog., 12:e1005411-e1005411, 2016

PubMed Abstract: Influenza viruses cause seasonal flu each year and pandemics or epidemic sporadically, posing a major threat to public health. Recently, a new influenza D virus (IDV) was isolated from pigs and cattle. Here, we reveal that the IDV utilizes 9-O-acetylated sialic acids as its receptor for virus entry. Then, we determined the crystal structures of hemagglutinin-esterase-fusion glycoprotein (HEF) of IDV both in its free form and in complex with the receptor and enzymatic substrate analogs. The IDV HEF shows an extremely similar structural fold as the human-infecting influenza C virus (ICV) HEF. However, IDV HEF has an open receptor-binding cavity to accommodate diverse extended glycan moieties. This structural difference provides an explanation for the phenomenon that the IDV has a broad cell tropism. As IDV HEF is structurally and functionally similar to ICV HEF, our findings highlight the potential threat of the virus to public health.

PubMed: 26816272
DOI: 10.1371/journal.ppat.1005411

実験手法

X-RAY DIFFRACTION (2.4 Å)