5E29

Crystal Structure of Deoxygenated Hemoglobin in Complex with an Allosteric Effector and Nitric Oxide

5E29 の概要

• エントリーDOI: 10.2210/pdb5e29/pdb
• 分子名称: Hemoglobin subunit alpha, Hemoglobin subunit beta, NITRIC OXIDE, ... (9 entities in total)
• 機能のキーワード: hemoglobin, right-shifter, nitric oxide, oxygen transport
• 由来する生物種: Homo sapiens (Human); 詳細
• タンパク質・核酸の鎖数: 4
• 化学式量合計: 65783.05

構造登録者

Safo, M.K.,Deshpande, T.M. (登録日: 2015-09-30, 公開日: 2015-10-14, 最終更新日: 2023-09-27)

• 主引用文献: Xu, G.G.,Deshpande, T.M.,Ghatge, M.S.,Mehta, A.Y.,Omar, A.S.,Ahmed, M.H.,Venitz, J.,Abdulmalik, O.,Zhang, Y.,Safo, M.K.; Design, Synthesis, and Investigation of Novel Nitric Oxide (NO)-Releasing Prodrugs as Drug Candidates for the Treatment of Ischemic Disorders: Insights into NO-Releasing Prodrug Biotransformation and Hemoglobin-NO Biochemistry.; Biochemistry, 54:7178-7192, 2015; PubMed: 26582149; DOI: 10.1021/acs.biochem.5b01074

実験手法

X-RAY DIFFRACTION (1.85 Å)