5E0E

Crystal Structure of Cytochrome P450 2B37 from Desert Woodrat in complex with 4-(4-chlorophenyl)imidazole

5E0E の概要

• エントリーDOI: 10.2210/pdb5e0e/pdb
• 分子名称: Cytochrome P450 family 2 subfamily B, PROTOPORPHYRIN IX CONTAINING FE, 4-(4-CHLOROPHENYL)IMIDAZOLE, ... (4 entities in total)
• 機能のキーワード: cytochrome p450, cyp2b37, 4-(4-chlorophenyl)imidazole, inhibitor, oxidoreductase-oxidoreductase inhibitor complex, oxidoreductase/oxidoreductase inhibitor
• 由来する生物種: Neotoma lepida (Desert woodrat)
• タンパク質・核酸の鎖数: 1
• 化学式量合計: 54351.20

構造登録者

Shah, M.B.,Halpert, J.R.,Stout, C.D. (登録日: 2015-09-28, 公開日: 2016-02-10, 最終更新日: 2023-09-27)

• 主引用文献: Shah, M.B.,Liu, J.,Huo, L.,Zhang, Q.,Dearing, M.D.,Wilderman, P.R.,Szklarz, G.D.,Stout, C.D.,Halpert, J.R.; Structure-Function Analysis of Mammalian CYP2B Enzymes Using 7-Substituted Coumarin Derivatives as Probes: Utility of Crystal Structures and Molecular Modeling in Understanding Xenobiotic Metabolism.; Mol.Pharmacol., 89:435-445, 2016; PubMed: 26826176; DOI: 10.1124/mol.115.102111

実験手法

X-RAY DIFFRACTION (3.4 Å)