5DYZ

Crystal structure of Asp251Gly/Gln307His mutant of cytochrome P450 BM3 in complex with N-palmitoylglycine

5DYZ の概要

• エントリーDOI: 10.2210/pdb5dyz/pdb
• 分子名称: Bifunctional P-450/NADPH-P450 reductase, PROTOPORPHYRIN IX CONTAINING FE, N-PALMITOYLGLYCINE, ... (4 entities in total)
• 機能のキーワード: cytochrome p450, random mutagenesis, drug metabolism, substrate, oxidoreductase
• 由来する生物種: Bacillus megaterium
• 細胞内の位置: Cytoplasm : P14779
• タンパク質・核酸の鎖数: 2
• 化学式量合計: 108728.61

構造登録者

Di Nardo, G.,Dell'Angelo, V.,Gilardi, G. (登録日: 2015-09-25, 公開日: 2016-01-20, 最終更新日: 2024-01-10)

• 主引用文献: Di Nardo, G.,Dell'Angelo, V.,Catucci, G.,Sadeghi, S.J.,Gilardi, G.; Subtle structural changes in the Asp251Gly/Gln307His P450 BM3 mutant responsible for new activity toward diclofenac, tolbutamide and ibuprofen.; Arch.Biochem.Biophys., 602:106-115, 2016; PubMed: 26718083; DOI: 10.1016/j.abb.2015.12.005

実験手法

X-RAY DIFFRACTION (1.967 Å)