5DYW

Crystal structure of human butyrylcholinesterase in complex with N-((1-benzylpiperidin-3-yl)methyl)-N-(2-methoxyethyl)naphthalene-2-sulfonamide

5DYW の概要

• エントリーDOI: 10.2210/pdb5dyw/pdb
• 分子名称: Cholinesterase, 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, ... (11 entities in total)
• 機能のキーワード: hydrolase, human butyrylcholinesterase ad alzheimer disease sulfonamide
• 由来する生物種: Homo sapiens (Human)
• タンパク質・核酸の鎖数: 2
• 化学式量合計: 128169.43

構造登録者

Coquelle, N.,Brus, B.,Colletier, J.P. (登録日: 2015-09-25, 公開日: 2017-01-18, 最終更新日: 2024-05-01)

• 主引用文献: Kosak, U.,Brus, B.,Knez, D.,Sink, R.,Zakelj, S.,Trontelj, J.,Pislar, A.,Slenc, J.,Gobec, M.,Zivin, M.,Tratnjek, L.,Perse, M.,Saat, K.,Podkowa, A.,Filipek, B.,Nachon, F.,Brazzolotto, X.,Wieckowska, A.,Malawska, B.,Stojan, J.,Rascan, I.M.,Kos, J.,Coquelle, N.,Colletier, J.P.,Gobec, S.; Development of an in-vivo active reversible butyrylcholinesterase inhibitor.; Sci Rep, 6:39495-39495, 2016; PubMed: 28000737; DOI: 10.1038/srep39495

実験手法

X-RAY DIFFRACTION (2.5 Å)