5DYM

Crystal structure of a PadR family transcription regulator from hypervirulent Clostridium difficile R20291 - CdPadR_0991 to 1.89 Angstrom resolution

5DYM の概要

• エントリーDOI: 10.2210/pdb5dym/pdb
• 分子名称: PadR-family transcriptional regulator (2 entities in total)
• 機能のキーワード: padr, whth dna binding domain, helix turn helix motifs, transcription regulator, padr-s2, dna binding protein
• 由来する生物種: Peptoclostridium difficile (strain R20291)
• タンパク質・核酸の鎖数: 1
• 化学式量合計: 14112.26

構造登録者

Isom, C.E.,Karr, E.A.,Menon, S.K.,West, A.H.,Richter-Addo, G.B. (登録日: 2015-09-24, 公開日: 2016-10-05, 最終更新日: 2023-09-27)

主引用文献

Isom, C.E.,Menon, S.K.,Thomas, L.M.,West, A.H.,Richter-Addo, G.B.,Karr, E.A.
Crystal structure and DNA binding activity of a PadR family transcription regulator from hypervirulent Clostridium difficile R20291.
Bmc Microbiol., 16:231-231, 2016

PubMed Abstract: Clostridium difficile is a spore-forming obligate anaerobe that can remain viable for extended periods, even in the presence of antibiotics, which contributes to the persistence of this bacterium as a human pathogen during host-to-host transmission and in hospital environments. We examined the structure and function of a gene product with the locus tag CDR20291_0991 (cdPadR1) as part of our broader goal aimed at elucidating transcription regulatory mechanisms involved in virulence and antibiotic resistance of the recently emergent hypervirulent C. difficile strain R20291. cdPadR1 is genomically positioned near genes that are involved in stress response and virulence. In addition, it was previously reported that cdPadR1 and a homologue from the historical C. difficile strain 630 (CD630_1154) were differentially expressed when exposed to stressors, including antibiotics.

PubMed: 27716049
DOI: 10.1186/s12866-016-0850-0

実験手法

X-RAY DIFFRACTION (1.894 Å)