5DUA

First condensation domain of the calcium-dependent antibiotic synthetase in complex with substrate analogue 3a

Summary for 5DUA

• Entry DOI: 10.2210/pdb5dua/pdb
• Related: 5DU9
• Descriptor: CDA peptide synthetase I, N-pentyl-L-alaninamide, CHLORIDE ION, ... (4 entities in total)
• Functional Keywords: nonribosomal peptide synthetase, condensation domain, chemical probe, substrate analogue, phosphopantetheine binding protein
• Biological source: Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)
• Total number of polymer chains: 2
• Total formula weight: 97368.93

Authors

Bloudoff, K.,Alonzo, D.A.,Schmeing, T.M. (deposition date: 2015-09-18, release date: 2016-03-30, Last modification date: 2020-01-08)

• Primary citation: Bloudoff, K.,Alonzo, D.A.,Schmeing, T.M.; Chemical Probes Allow Structural Insight into the Condensation Reaction of Nonribosomal Peptide Synthetases.; Cell Chem Biol, 23:331-339, 2016; PubMed: 26991102; DOI: 10.1016/j.chembiol.2016.02.012

Experimental method

X-RAY DIFFRACTION (1.9 Å)