5DLZ
FIRST DOMAIN OF HUMAN BROMODOMAIN BRD4 IN COMPLEX WITH INHIBITOR 4-[(1-methyl-2-oxo-1,2-dihydroquinolin-4-yl)oxy]-N-({1-[(3-methylphe methyl]piperidin-4-yl}methyl)butanamide
5DLZ の概要
エントリーDOI | 10.2210/pdb5dlz/pdb |
分子名称 | Bromodomain-containing protein 4, N-{[1-(3-methylbenzyl)piperidin-4-yl]methyl}-4-[(1-methyl-2-oxo-1,2-dihydroquinolin-4-yl)oxy]butanamide (3 entities in total) |
機能のキーワード | inhibitor, histone, epigenetic reader, bromodomain, brd4, brd4_bd1, transcription |
由来する生物種 | Homo sapiens (Human) |
タンパク質・核酸の鎖数 | 1 |
化学式量合計 | 15560.98 |
構造登録者 | |
主引用文献 | Milhas, S.,Raux, B.,Betzi, S.,Derviaux, C.,Roche, P.,Restouin, A.,Basse, M.J.,Rebuffet, E.,Lugari, A.,Badol, M.,Kashyap, R.,Lissitzky, J.C.,Eydoux, C.,Hamon, V.,Gourdel, M.E.,Combes, S.,Zimmermann, P.,Aurrand-Lions, M.,Roux, T.,Rogers, C.,Muller, S.,Knapp, S.,Trinquet, E.,Collette, Y.,Guillemot, J.C.,Morelli, X. Protein-Protein Interaction Inhibition (2P2I)-Oriented Chemical Library Accelerates Hit Discovery. Acs Chem.Biol., 11:2140-2148, 2016 Cited by PubMed: 27219844DOI: 10.1021/acschembio.6b00286 主引用文献が同じPDBエントリー |
実験手法 | X-RAY DIFFRACTION (1.7 Å) |
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