5DLX

FIRST DOMAIN OF HUMAN BROMODOMAIN BRD4 IN COMPLEX WITH INHIBITOR N-{3-[4-(3-chlorophenyl)piperazin-1-yl]propyl}-1-{3-methyl-[1,2,4]triazolo[4,3-b]pyridazin-6-yl}piperidine-4-carboxamide

5DLX の概要

• エントリーDOI: 10.2210/pdb5dlx/pdb
• 分子名称: Bromodomain-containing protein 4, N-{3-[4-(3-chlorophenyl)piperazin-1-yl]propyl}-1-(3-methyl[1,2,4]triazolo[4,3-b]pyridazin-6-yl)piperidine-4-carboxamide (3 entities in total)
• 機能のキーワード: inhibitor, histone, epigenetic reader, bromodomain, brd4, brd4_bd1, transcription
• 由来する生物種: Homo sapiens (Human)
• 細胞内の位置: Nucleus: O60885
• タンパク質・核酸の鎖数: 1
• 化学式量合計: 15596.42

構造登録者

Raux, B.,Rebuffet, E.,Betzi, S.,Morelli, X. (登録日: 2015-09-07, 公開日: 2016-06-01, 最終更新日: 2024-01-10)

• 主引用文献: Milhas, S.,Raux, B.,Betzi, S.,Derviaux, C.,Roche, P.,Restouin, A.,Basse, M.J.,Rebuffet, E.,Lugari, A.,Badol, M.,Kashyap, R.,Lissitzky, J.C.,Eydoux, C.,Hamon, V.,Gourdel, M.E.,Combes, S.,Zimmermann, P.,Aurrand-Lions, M.,Roux, T.,Rogers, C.,Muller, S.,Knapp, S.,Trinquet, E.,Collette, Y.,Guillemot, J.C.,Morelli, X.; Protein-Protein Interaction Inhibition (2P2I)-Oriented Chemical Library Accelerates Hit Discovery.; Acs Chem.Biol., 11:2140-2148, 2016; PubMed: 27219844; DOI: 10.1021/acschembio.6b00286

実験手法

X-RAY DIFFRACTION (1.9 Å)