5DLS

Identification of Novel, in vivo Active Chk1 Inhibitors Utilizing Structure Guided Drug Design

5DLS の概要

• エントリーDOI: 10.2210/pdb5dls/pdb
• 分子名称: Serine/threonine-protein kinase Chk1, 1-benzyl-N-(5-{5-[3-(dimethylamino)-2,2-dimethylpropoxy]-1H-indol-2-yl}-6-oxo-1,6-dihydropyridin-3-yl)-1H-pyrazole-4-carboxamide, SULFATE ION, ... (4 entities in total)
• 機能のキーワード: chk1, v158411, fragment, kinase, transferase
• 由来する生物種: Homo sapiens (Human)
• 細胞内の位置: Nucleus: O14757
• タンパク質・核酸の鎖数: 1
• 化学式量合計: 34782.85

構造登録者

Massey, A.J.,Stokes, S.,Browne, H.,Foloppe, N.,Fiumana, A.,Scrace, S.,Fallowfield, M.,Bedford, S.,Webb, P.,Baker, L.M.,Christie, M.,Drysdale, M.J.,Wood, M. (登録日: 2015-09-07, 公開日: 2015-10-14, 最終更新日: 2024-01-10)

• 主引用文献: Massey, A.J.,Stokes, S.,Browne, H.,Foloppe, N.,Fiumana, A.,Scrace, S.,Fallowfield, M.,Bedford, S.,Webb, P.,Baker, L.,Christie, M.,Drysdale, M.J.,Wood, M.; Identification of novel, in vivo active Chk1 inhibitors utilizing structure guided drug design.; Oncotarget, 6:35797-35812, 2015; PubMed: 26437226; DOI: 10.18632/oncotarget.5929

実験手法

X-RAY DIFFRACTION (2.15 Å)