5DLM

Complex of Influenza M2e and Antibody

5DLM の概要

• エントリーDOI: 10.2210/pdb5dlm/pdb
• 分子名称: Heavy chain of monoclonal antibody, Light chain of monoclonal antibody, Matrix protein 2, ... (5 entities in total)
• 機能のキーワード: complex, antibody, extracellular domain, immune system
• 由来する生物種: Mus musculus (House Mouse); 詳細
• 細胞内の位置: Virion membrane : A4U6V3
• タンパク質・核酸の鎖数: 6
• 化学式量合計: 99240.48

構造登録者

Cho, K.J.,Schepens, B.,Moonens, K.,Deng, L.,Fiers, W.,Remaut, H.,Saelens, X. (登録日: 2015-09-07, 公開日: 2015-10-28, 最終更新日: 2024-11-13)

主引用文献

Cho, K.J.,Schepens, B.,Moonens, K.,Deng, L.,Fiers, W.,Remaut, H.,Saelens, X.
Crystal Structure of the Conserved Amino Terminus of the Extracellular Domain of Matrix Protein 2 of Influenza A Virus Gripped by an Antibody.
J.Virol., 90:611-615, 2015

PubMed Abstract: We report the crystal structure of the M2 ectodomain (M2e) in complex with a monoclonal antibody that binds the amino terminus of M2. M2e extends into the antibody binding site to form an N-terminal β-turn near the bottom of the paratope. This M2e folding differs significantly from that of M2e in complex with an antibody that binds another part of M2e. This suggests that M2e can adopt at least two conformations that can elicit protective antibodies.

PubMed: 26468526
DOI: 10.1128/JVI.02105-15

実験手法

X-RAY DIFFRACTION (2.2 Å)