5DHU

Crystal structure of NAD kinase 1 from Listeria monocytogenes in complex with a novel inhibitor

Summary for 5DHU

Entry DOI	10.2210/pdb5dhu/pdb
Related	5DHP 5DHQ 5DHR 5DHS 5DHT
Descriptor	NAD kinase 1, GLYCEROL, 5'-azido-5'-deoxy-8-[(2-{[2-(1H-indol-3-yl)ethyl]amino}-2-oxoethyl)sulfanyl]adenosine, ... (5 entities in total)
Functional Keywords	tetrameric nad kinase, transferase
Biological source	Listeria monocytogenes serovar 1/2a (strain ATCC BAA-679 / EGD-e)
Cellular location	Cytoplasm : Q8Y8D7
Total number of polymer chains	4
Total formula weight	126563.56
Authors	Gelin, M.,Paoletti, J.,Assairi, L.,Huteau, V.,Pochet, S.,Labesse, G. (deposition date: 2015-08-31, release date: 2016-09-14, Last modification date: 2024-01-10)
Primary citation	Paoletti, J.,Assairi, L.,Gelin, M.,Huteau, V.,Nahori, M.A.,Dussurget, O.,Labesse, G.,Pochet, S. 8-Thioalkyl-adenosine derivatives inhibit Listeria monocytogenes NAD kinase through a novel binding mode. Eur.J.Med.Chem., 124:1041-1056, 2016 Cited by PubMed: 27783975 DOI: 10.1016/j.ejmech.2016.10.033 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (2.33 Å)

Structure validation