5DH3

Crystal structure of MST2 in complex with XMU-MP-1

5DH3 の概要

• エントリーDOI: 10.2210/pdb5dh3/pdb
• 分子名称: Serine/threonine-protein kinase 3, 4-[(5,10-dimethyl-6-oxo-6,10-dihydro-5H-pyrimido[5,4-b]thieno[3,2-e][1,4]diazepin-2-yl)amino]benzenesulfonamide, CHLORIDE ION, ... (5 entities in total)
• 機能のキーワード: mst2, mst1, hippo pathway, transferase-transferase inhibitor complex, transferase/transferase inhibitor
• 由来する生物種: Homo sapiens (Human)
• 細胞内の位置: Cytoplasm : Q13188
• タンパク質・核酸の鎖数: 2
• 化学式量合計: 72443.98

構造登録者

Kong, L.L.,Yun, C.H. (登録日: 2015-08-29, 公開日: 2016-08-31, 最終更新日: 2023-11-08)

• 主引用文献: Fan, F.,He, Z.,Kong, L.L.,Chen, Q.,Yuan, Q.,Zhang, S.,Ye, J.,Liu, H.,Sun, X.,Geng, J.,Yuan, L.,Hong, L.,Xiao, C.,Zhang, W.,Sun, X.,Li, Y.,Wang, P.,Huang, L.,Wu, X.,Ji, Z.,Wu, Q.,Xia, N.S.,Gray, N.S.,Chen, L.,Yun, C.H.,Deng, X.,Zhou, D.; Pharmacological targeting of kinases MST1 and MST2 augments tissue repair and regeneration; Sci Transl Med, 8:352ra108-352ra108, 2016; PubMed: 27535619; DOI: 10.1126/scitranslmed.aaf2304

実験手法

X-RAY DIFFRACTION (2.468 Å)