5DGW
Crystal Structure of HIV-1 Protease Inhibitor GRL-105-11A Containing Substituted fused-Tetrahydropyranyl Tetrahydrofuran as P2-Ligand
Summary for 5DGW
Entry DOI | 10.2210/pdb5dgw/pdb |
Descriptor | Pol protein, (3R,3aS,4S,7aS)-3-(ethylamino)hexahydro-4H-furo[2,3-b]pyran-4-yl [(2S,3R)-3-hydroxy-4-{[(4-methoxyphenyl)sulfonyl](2-methylpropyl)amino}-1-phenylbutan-2-yl]carbamate, SODIUM ION, ... (5 entities in total) |
Functional Keywords | hiv-1 protease, enzyme, hydrolase, hydrolase inhibitor |
Biological source | Human immunodeficiency virus 1 |
Total number of polymer chains | 2 |
Total formula weight | 22230.47 |
Authors | Agniswamy, J.,Wang, Y.-F.,Weber, I.T. (deposition date: 2015-08-28, release date: 2015-10-28, Last modification date: 2023-09-27) |
Primary citation | Ghosh, A.K.,Martyr, C.D.,Kassekert, L.A.,Nyalapatla, P.R.,Steffey, M.,Agniswamy, J.,Wang, Y.F.,Weber, I.T.,Amano, M.,Mitsuya, H. Design, synthesis, biological evaluation and X-ray structural studies of HIV-1 protease inhibitors containing substituted fused-tetrahydropyranyl tetrahydrofuran as P2-ligands. Org.Biomol.Chem., 13:11607-11621, 2015 Cited by PubMed: 26462551DOI: 10.1039/c5ob01930c PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (1.62 Å) |
Structure validation
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