5DGW

Crystal Structure of HIV-1 Protease Inhibitor GRL-105-11A Containing Substituted fused-Tetrahydropyranyl Tetrahydrofuran as P2-Ligand

5DGW の概要

• エントリーDOI: 10.2210/pdb5dgw/pdb
• 分子名称: Pol protein, (3R,3aS,4S,7aS)-3-(ethylamino)hexahydro-4H-furo[2,3-b]pyran-4-yl [(2S,3R)-3-hydroxy-4-{[(4-methoxyphenyl)sulfonyl](2-methylpropyl)amino}-1-phenylbutan-2-yl]carbamate, SODIUM ION, ... (5 entities in total)
• 機能のキーワード: hiv-1 protease, enzyme, hydrolase, hydrolase inhibitor
• 由来する生物種: Human immunodeficiency virus 1
• タンパク質・核酸の鎖数: 2
• 化学式量合計: 22230.47

構造登録者

Agniswamy, J.,Wang, Y.-F.,Weber, I.T. (登録日: 2015-08-28, 公開日: 2015-10-28, 最終更新日: 2023-09-27)

• 主引用文献: Ghosh, A.K.,Martyr, C.D.,Kassekert, L.A.,Nyalapatla, P.R.,Steffey, M.,Agniswamy, J.,Wang, Y.F.,Weber, I.T.,Amano, M.,Mitsuya, H.; Design, synthesis, biological evaluation and X-ray structural studies of HIV-1 protease inhibitors containing substituted fused-tetrahydropyranyl tetrahydrofuran as P2-ligands.; Org.Biomol.Chem., 13:11607-11621, 2015; PubMed: 26462551; DOI: 10.1039/c5ob01930c

実験手法

X-RAY DIFFRACTION (1.62 Å)