5DAD
Crystal Structure of Human KEAP1 BTB Domain in Complex with Small Molecule TX64014
Summary for 5DAD
Entry DOI | 10.2210/pdb5dad/pdb |
Related | 5DAF |
Descriptor | Kelch-like ECH-associated protein 1, (6aS,7S,10aS)-8-hydroxy-4-methoxy-2,7,10a-trimethyl-5,6,6a,7,10,10a-hexahydrobenzo[h]quinazoline-9-carbonitrile (3 entities in total) |
Functional Keywords | keap1, trascription regulation, btb domain, cysteine modification, c1-(r)-cys151 adduct, transcription |
Biological source | Homo sapiens (Human) |
Cellular location | Cytoplasm: Q14145 |
Total number of polymer chains | 1 |
Total formula weight | 15894.32 |
Authors | Huerta, C.,Jiang, X.,Trevino, I.,Bender, C.F.,Swinger, K.K.,Stoll, V.S.,Ferguson, D.A.,Thomas, P.J.,Probst, B.,Dulubova, I.,Visnick, M.,Wigley, W.C. (deposition date: 2015-08-19, release date: 2016-08-10, Last modification date: 2023-09-27) |
Primary citation | Huerta, C.,Jiang, X.,Trevino, I.,Bender, C.F.,Ferguson, D.A.,Probst, B.,Swinger, K.K.,Stoll, V.S.,Thomas, P.J.,Dulubova, I.,Visnick, M.,Wigley, W.C. Characterization of novel small-molecule NRF2 activators: Structural and biochemical validation of stereospecific KEAP1 binding. Biochim.Biophys.Acta, 1860:2537-2552, 2016 Cited by PubMed: 27474998DOI: 10.1016/j.bbagen.2016.07.026 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2.61 Å) |
Structure validation
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