5D3F

Crystal structure of human 14-3-3 zeta in complex with CFTR R-domain peptide pS753-pS768 and stabilizer fusicoccin-A

5D3F の概要

• エントリーDOI: 10.2210/pdb5d3f/pdb
• 分子名称: 14-3-3 protein zeta/delta, Cystic fibrosis transmembrane conductance regulator, FUSICOCCIN (3 entities in total)
• 機能のキーワード: signaling protein, protein-peptide complex, phosphorylation, tandem binding, stabilization, fusicoccin-a, structural genomics, eindhoven university of technology
• 由来する生物種: Homo sapiens (Human); 詳細
• タンパク質・核酸の鎖数: 3
• 化学式量合計: 56571.00

構造登録者

Stevers, L.M.,Leysen, S.F.R.,Ottmann, C. (登録日: 2015-08-06, 公開日: 2016-03-16, 最終更新日: 2019-03-13)

• 主引用文献: Stevers, L.M.,Lam, C.V.,Leysen, S.F.,Meijer, F.A.,van Scheppingen, D.S.,de Vries, R.M.,Carlile, G.W.,Milroy, L.G.,Thomas, D.Y.,Brunsveld, L.,Ottmann, C.; Characterization and small-molecule stabilization of the multisite tandem binding between 14-3-3 and the R domain of CFTR.; Proc.Natl.Acad.Sci.USA, 113:E1152-E1161, 2016; PubMed: 26888287; DOI: 10.1073/pnas.1516631113

実験手法

X-RAY DIFFRACTION (2.74 Å)