5CXA

Crystal structure of the catalytic domain of Human MMP12 in complex with a carboxylate inhibitor related to RXP470

Summary for 5CXA

• Entry DOI: 10.2210/pdb5cxa/pdb
• Related: 4GQL 4GR0 4GR3 4GR8
• Descriptor: Macrophage metalloelastase, ZINC ION, CALCIUM ION, ... (5 entities in total)
• Functional Keywords: metzincin, rxp470, carboxylate based inhibitor, carboxylate peptidic inhibitor, hydrolase
• Biological source: Homo sapiens (Human); More
• Cellular location: Secreted, extracellular space, extracellular matrix : P39900
• Total number of polymer chains: 1
• Total formula weight: 18451.66

Authors

Rouanet-Mehouas, C.,Devel, L.,Dive, V.,Stura, E.A. (deposition date: 2015-07-28, release date: 2016-08-10, Last modification date: 2024-01-10)

• Primary citation: Rouanet-Mehouas, C.,Czarny, B.,Beau, F.,Cassar-Lajeunesse, E.,Stura, E.A.,Dive, V.,Devel, L.; Zinc-Metalloproteinase Inhibitors: Evaluation of the Complex Role Played by the Zinc-Binding Group on Potency and Selectivity.; J. Med. Chem., 60:403-414, 2017; PubMed: 27996256; DOI: 10.1021/acs.jmedchem.6b01420

Experimental method

X-RAY DIFFRACTION (1.3 Å)