5CXA

Crystal structure of the catalytic domain of Human MMP12 in complex with a carboxylate inhibitor related to RXP470

5CXA の概要

• エントリーDOI: 10.2210/pdb5cxa/pdb
• 関連するPDBエントリー: 4GQL 4GR0 4GR3 4GR8
• 分子名称: Macrophage metalloelastase, ZINC ION, CALCIUM ION, ... (5 entities in total)
• 機能のキーワード: metzincin, rxp470, carboxylate based inhibitor, carboxylate peptidic inhibitor, hydrolase
• 由来する生物種: Homo sapiens (Human); 詳細
• 細胞内の位置: Secreted, extracellular space, extracellular matrix : P39900
• タンパク質・核酸の鎖数: 1
• 化学式量合計: 18451.66

構造登録者

Rouanet-Mehouas, C.,Devel, L.,Dive, V.,Stura, E.A. (登録日: 2015-07-28, 公開日: 2016-08-10, 最終更新日: 2024-01-10)

• 主引用文献: Rouanet-Mehouas, C.,Czarny, B.,Beau, F.,Cassar-Lajeunesse, E.,Stura, E.A.,Dive, V.,Devel, L.; Zinc-Metalloproteinase Inhibitors: Evaluation of the Complex Role Played by the Zinc-Binding Group on Potency and Selectivity.; J. Med. Chem., 60:403-414, 2017; PubMed: 27996256; DOI: 10.1021/acs.jmedchem.6b01420

実験手法

X-RAY DIFFRACTION (1.3 Å)