5CVF

Crystal Structure of CK2alpha with Compound 5 bound

5CVF の概要

• エントリーDOI: 10.2210/pdb5cvf/pdb
• 分子名称: Casein kinase II subunit alpha, 1-[3-chloro-4-(trifluoromethoxy)phenyl]methanamine, ADENOSINE-5'-TRIPHOSPHATE, ... (5 entities in total)
• 機能のキーワード: ck2alpha, ck2a, fragment based drug discovery, high concentration screening, selective atp competitive inhibitors, surface entrophy reduction, transferase
• 由来する生物種: Homo sapiens (Human)
• 細胞内の位置: Nucleus : P68400
• タンパク質・核酸の鎖数: 1
• 化学式量合計: 39882.26

構造登録者

Brear, P.,De Fusco, C.,Georgiou, K.H.,Spring, D.,Hyvonen, M. (登録日: 2015-07-26, 公開日: 2016-07-27, 最終更新日: 2024-01-10)

• 主引用文献: Brear, P.,De Fusco, C.,Hadje Georgiou, K.,Francis-Newton, N.J.,Stubbs, C.J.,Sore, H.F.,Venkitaraman, A.R.,Abell, C.,Spring, D.R.,Hyvonen, M.; Specific inhibition of CK2 alpha from an anchor outside the active site.; Chem Sci, 7:6839-6845, 2016; PubMed: 28451126; DOI: 10.1039/c6sc02335e

実験手法

X-RAY DIFFRACTION (1.63 Å)