5CS1
The structure of the NK1 fragment of HGF/SF
Summary for 5CS1
| Entry DOI | 10.2210/pdb5cs1/pdb |
| Descriptor | Hepatocyte growth factor (2 entities in total) |
| Functional Keywords | hgf/sf, nk1 fragment, fragment based drug discovery, growth factor, cell cycle, hormone, new chemical entity |
| Biological source | Homo sapiens (Human) |
| Total number of polymer chains | 2 |
| Total formula weight | 42344.55 |
| Authors | Sigurdardottir, A.G.,Winter, A.,Sobkowicz, A.,Fragai, M.,Chirgadze, D.Y.,Ascher, D.B.,Blundell, T.L.,Gherardi, E. (deposition date: 2015-07-23, release date: 2015-08-12, Last modification date: 2024-01-10) |
| Primary citation | Sigurdardottir, A.G.,Winter, A.,Sobkowicz, A.,Fragai, M.,Chirgadze, D.,Ascher, D.B.,Blundell, T.L.,Gherardi, E. Exploring the chemical space of the lysine-binding pocket of the first kringle domain of hepatocyte growth factor/scatter factor (HGF/SF) yields a new class of inhibitors of HGF/SF-MET binding. Chem Sci, 6:6147-6157, 2015 Cited by PubMed: 30090230DOI: 10.1039/c5sc02155c PDB entries with the same primary citation |
| Experimental method | X-RAY DIFFRACTION (2 Å) |
Structure validation
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