5CR7

Human cytosolic 5'-nucleotidase II in complex with N-(9H-Purin-6-yl)-3-(3-pyrrol-1-ylphenyl)benzamide

Summary for 5CR7

• Entry DOI: 10.2210/pdb5cr7/pdb
• Related: 4H4B 5CQZ
• Descriptor: Cytosolic purine 5'-nucleotidase, ~{N}-(7~{H}-purin-6-yl)-3-(3-pyrrol-1-ylphenyl)benzamide, ACETATE ION, ... (7 entities in total)
• Functional Keywords: complex, hydrolase
• Biological source: Homo sapiens (Human)
• Cellular location: Cytoplasm: P49902
• Total number of polymer chains: 2
• Total formula weight: 130803.21

Authors

Aghajari, N.,Preeti, P. (deposition date: 2015-07-22, release date: 2016-01-13, Last modification date: 2024-01-10)

• Primary citation: Marton, Z.,Guillon, R.,Krimm, I.,Rahimova, R.,Egron, D.,Jordheim, L.P.,Aghajari, N.,Dumontet, C.,Perigaud, C.,Lionne, C.,Peyrottes, S.,Chaloin, L.; Identification of Noncompetitive Inhibitors of Cytosolic 5'-Nucleotidase II Using a Fragment-Based Approach.; J.Med.Chem., 58:9680-9696, 2015; PubMed: 26599519; DOI: 10.1021/acs.jmedchem.5b01616

Experimental method

X-RAY DIFFRACTION (2.9 Å)