5CQW

Tetragonal Complex Structure of Protein Kinase CK2 Catalytic Subunit with a Benzotriazole-Based Inhibitor Generated by click-chemistry

Replaces:  4BXA

Summary for 5CQW

• Entry DOI: 10.2210/pdb5cqw/pdb
• Related: 5CQU
• Descriptor: Casein kinase II subunit alpha, 4-[4-[2-[4,5,6,7-tetrakis(bromanyl)benzotriazol-2-yl]ethyl]-1,2,3-triazol-1-yl]butan-1-amine, SULFATE ION, ... (6 entities in total)
• Functional Keywords: transferase, atp-competitive inhibitor, protein kinase ck2, casein kinase 2
• Biological source: Homo sapiens (Human)
• Cellular location: Nucleus : P68400
• Total number of polymer chains: 2
• Total formula weight: 82831.32

Authors

Niefind, K.,Schnitzler, A.,Swider, R.,Maslyk, M.,Ramos, A. (deposition date: 2015-07-22, release date: 2015-09-09, Last modification date: 2024-01-10)

• Primary citation: Swider, R.,Maslyk, M.,Zapico, J.M.,Coderch, C.,Panchuk, R.,Skorokhyd, N.,Schnitzler, A.,Niefind, K.,de Pascual-Teresa, B.,Ramos, A.; Synthesis, Biological Activity and Structural Study of New Benzotriazole-Based Protein Kinase CK2 Inhibitors; Rsc Adv, 5:72482-72494, 2015; DOI: 10.1039/C5RA12114K

Experimental method

X-RAY DIFFRACTION (2.65 Å)