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5CQU

Monoclinic Complex Structure of Protein Kinase CK2 Catalytic Subunit with a Benzotriazole-Based Inhibitor Generated by click-chemistry

Replaces:  4BXB
Summary for 5CQU
Entry DOI10.2210/pdb5cqu/pdb
DescriptorCasein kinase II subunit alpha, 4-[4-[2-[4,5,6,7-tetrakis(bromanyl)benzotriazol-2-yl]ethyl]-1,2,3-triazol-1-yl]butan-1-amine, SULFATE ION, ... (5 entities in total)
Functional Keywordstransferase, atp-competitive inhibitor, protein kinase ck2, casein kinase 2
Biological sourceHomo sapiens (Human)
Cellular locationNucleus : P68400
Total number of polymer chains1
Total formula weight41136.08
Authors
Niefind, K.,Schnitzler, A.,Swider, R.,Maslyk, M.,Ramos, A. (deposition date: 2015-07-22, release date: 2015-09-09, Last modification date: 2024-01-10)
Primary citationSwider, R.,Maslyk, M.,Zapico, J.M.,Coderch, C.,Panchuk, R.,Skorokhyd, N.,Schnitzler, A.,Niefind, K.,de Pascual-Teresa, B.,Ramos, A.
Synthesis, Biological Activity and Structural Study of New Benzotriazole-Based Protein Kinase CK2 Inhibitors
Rsc Adv, 5:72482-72494, 2015
Cited by
DOI: 10.1039/C5RA12114K
PDB entries with the same primary citation
Experimental method
X-RAY DIFFRACTION (2.35 Å)
Structure validation

217705

건을2024-03-27부터공개중

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