5CPB
The effect of isoleucine to alanine mutation on InhA enzyme crystallization pattern and inhibition by ligand PT70 (TCU)
Summary for 5CPB
| Entry DOI | 10.2210/pdb5cpb/pdb |
| Related | 5COQ 5CP8 5CPF |
| Descriptor | Enoyl-[acyl-carrier-protein] reductase [NADH], NICOTINAMIDE-ADENINE-DINUCLEOTIDE (3 entities in total) |
| Functional Keywords | fatty acid biosynthesis inhibition, oxidoreductase |
| Biological source | Mycobacterium tuberculosis |
| Total number of polymer chains | 6 |
| Total formula weight | 188084.87 |
| Authors | Li, H.-J.,Lai, C.-T.,Liu, N.,Yu, W.,Shah, S.,Bommineni, G.R.,Perrone, V.,Garcia-Diaz, M.,Tonge, P.J.,Simmerling, C. (deposition date: 2015-07-21, release date: 2015-08-19, Last modification date: 2023-09-27) |
| Primary citation | Lai, C.T.,Li, H.J.,Yu, W.,Shah, S.,Bommineni, G.R.,Perrone, V.,Garcia-Diaz, M.,Tonge, P.J.,Simmerling, C. Rational Modulation of the Induced-Fit Conformational Change for Slow-Onset Inhibition in Mycobacterium tuberculosis InhA. Biochemistry, 54:4683-4691, 2015 Cited by PubMed: 26147157DOI: 10.1021/acs.biochem.5b00284 PDB entries with the same primary citation |
| Experimental method | X-RAY DIFFRACTION (1.997 Å) |
Structure validation
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