5COJ

Structure of Hydroxyethylthiazole kinase ThiM from Staphylococcus aureus in complex with native substrate 2-(4-methyl-1,3-thiazol-5-yl)ethanol.

5COJ の概要

• エントリーDOI: 10.2210/pdb5coj/pdb
• 関連するPDBエントリー: 5CGE 5CM5 5GCA
• 分子名称: Hydroxyethylthiazole kinase, 2-(4-METHYL-THIAZOL-5-YL)-ETHANOL, MAGNESIUM ION, ... (4 entities in total)
• 機能のキーワード: bacterial thiamine biosynthesis, hydroxyethylthiazole kinase, transferase, 2-(4-methyl-1, 3-thiazol-5-yl)ethanol
• 由来する生物種: Staphylococcus aureus
• タンパク質・核酸の鎖数: 6
• 化学式量合計: 179923.27

構造登録者

Drebes, J.,Kuenz, M.,Eberle, R.J.,Oberthuer, D.,Cang, H.,Wrenger, C.,Betzel, C. (登録日: 2015-07-20, 公開日: 2016-03-23, 最終更新日: 2024-05-08)

• 主引用文献: Drebes, J.,Kunz, M.,Windshugel, B.,Kikhney, A.G.,Muller, I.B.,Eberle, R.J.,Oberthur, D.,Cang, H.,Svergun, D.I.,Perbandt, M.,Betzel, C.,Wrenger, C.; Structure of ThiM from Vitamin B1 biosynthetic pathway of Staphylococcus aureus - Insights into a novel pro-drug approach addressing MRSA infections.; Sci Rep, 6:22871-22871, 2016; PubMed: 26960569; DOI: 10.1038/srep22871

実験手法

X-RAY DIFFRACTION (1.9 Å)