5CGV
2009 H1N1 PA endonuclease in complex with L-742,001
Summary for 5CGV
Entry DOI | 10.2210/pdb5cgv/pdb |
Descriptor | Polymerase acidic protein, MANGANESE (II) ION, (2Z)-4-[1-benzyl-4-(4-chlorobenzyl)piperidin-4-yl]-2-hydroxy-4-oxobut-2-enoic acid, ... (5 entities in total) |
Functional Keywords | influenza resistance endonuclease inhibitor, hydrolase-hydrolase inhibitor complex, hydrolase/hydrolase inhibitor |
Biological source | Influenza A virus |
Total number of polymer chains | 1 |
Total formula weight | 22586.02 |
Authors | Kumar, G.,White, S.W. (deposition date: 2015-07-09, release date: 2016-03-23, Last modification date: 2023-09-27) |
Primary citation | Song, M.S.,Kumar, G.,Shadrick, W.R.,Zhou, W.,Jeevan, T.,Li, Z.,Slavish, P.J.,Fabrizio, T.P.,Yoon, S.W.,Webb, T.R.,Webby, R.J.,White, S.W. Identification and characterization of influenza variants resistant to a viral endonuclease inhibitor. Proc. Natl. Acad. Sci. U.S.A., 113:3669-3674, 2016 Cited by PubMed: 26976575DOI: 10.1073/pnas.1519772113 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2.17 Å) |
Structure validation
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