5CGV

2009 H1N1 PA endonuclease in complex with L-742,001

5CGV の概要

• エントリーDOI: 10.2210/pdb5cgv/pdb
• 分子名称: Polymerase acidic protein, MANGANESE (II) ION, (2Z)-4-[1-benzyl-4-(4-chlorobenzyl)piperidin-4-yl]-2-hydroxy-4-oxobut-2-enoic acid, ... (5 entities in total)
• 機能のキーワード: influenza resistance endonuclease inhibitor, hydrolase-hydrolase inhibitor complex, hydrolase/hydrolase inhibitor
• 由来する生物種: Influenza A virus
• タンパク質・核酸の鎖数: 1
• 化学式量合計: 22586.02

構造登録者

Kumar, G.,White, S.W. (登録日: 2015-07-09, 公開日: 2016-03-23, 最終更新日: 2023-09-27)

• 主引用文献: Song, M.S.,Kumar, G.,Shadrick, W.R.,Zhou, W.,Jeevan, T.,Li, Z.,Slavish, P.J.,Fabrizio, T.P.,Yoon, S.W.,Webb, T.R.,Webby, R.J.,White, S.W.; Identification and characterization of influenza variants resistant to a viral endonuclease inhibitor.; Proc. Natl. Acad. Sci. U.S.A., 113:3669-3674, 2016; PubMed: 26976575; DOI: 10.1073/pnas.1519772113

実験手法

X-RAY DIFFRACTION (2.17 Å)