5CAS

EGFR kinase domain mutant "TMLR" with compound 41a

5CAS の概要

• エントリーDOI: 10.2210/pdb5cas/pdb
• 分子名称: Epidermal growth factor receptor, SULFATE ION, (1R)-1-{6-({2-[(3R,4S)-3-fluoro-4-methoxypiperidin-1-yl]pyrimidin-4-yl}amino)-1-[(2S)-1,1,1-trifluoropropan-2-yl]-1H-imidazo[4,5-c]pyridin-2-yl}ethanol, ... (4 entities in total)
• 機能のキーワード: protein kinase inhibitor, transferase-transferase inhibitor complex, transferase/transferase inhibitor
• 由来する生物種: Homo sapiens (Human)
• 細胞内の位置: Cell membrane; Single-pass type I membrane protein. Isoform 2: Secreted: P00533
• タンパク質・核酸の鎖数: 1
• 化学式量合計: 38128.92

構造登録者

Eigenbrot, C.,Yu, C. (登録日: 2015-06-29, 公開日: 2015-10-28, 最終更新日: 2024-03-06)

• 主引用文献: Heald, R.,Bowman, K.K.,Bryan, M.C.,Burdick, D.,Chan, B.,Chan, E.,Chen, Y.,Clausen, S.,Dominguez-Fernandez, B.,Eigenbrot, C.,Elliott, R.,Hanan, E.J.,Jackson, P.,Knight, J.,La, H.,Lainchbury, M.,Malek, S.,Mann, S.,Merchant, M.,Mortara, K.,Purkey, H.,Schaefer, G.,Schmidt, S.,Seward, E.,Sideris, S.,Shao, L.,Wang, S.,Yeap, K.,Yen, I.,Yu, C.,Heffron, T.P.; Noncovalent Mutant Selective Epidermal Growth Factor Receptor Inhibitors: A Lead Optimization Case Study.; J.Med.Chem., 58:8877-8895, 2015; PubMed: 26455919; DOI: 10.1021/acs.jmedchem.5b01412

実験手法

X-RAY DIFFRACTION (2.1 Å)