5C9C

CRYSTAL STRUCTURE OF BRAF(V600E) IN COMPLEX WITH LY3009120 COMPND

5C9C の概要

• エントリーDOI: 10.2210/pdb5c9c/pdb
• 分子名称: Serine/threonine-protein kinase B-raf, 1-(3,3-dimethylbutyl)-3-{2-fluoro-4-methyl-5-[7-methyl-2-(methylamino)pyrido[2,3-d]pyrimidin-6-yl]phenyl}urea, CHLORIDE ION, ... (4 entities in total)
• 機能のキーワード: transferase-transferase inhibitor complex, transferase/transferase inhibitor
• 由来する生物種: Homo sapiens (Human)
• 細胞内の位置: Nucleus : P15056
• タンパク質・核酸の鎖数: 2
• 化学式量合計: 71379.71

構造登録者

Edwards, T.,Abendroth, J.,Chun, L. (登録日: 2015-06-26, 公開日: 2015-07-15, 最終更新日: 2023-09-27)

• 主引用文献: Peng, S.B.,Henry, J.R.,Kaufman, M.D.,Lu, W.P.,Smith, B.D.,Vogeti, S.,Rutkoski, T.J.,Wise, S.,Chun, L.,Zhang, Y.,Van Horn, R.D.,Yin, T.,Zhang, X.,Yadav, V.,Chen, S.H.,Gong, X.,Ma, X.,Webster, Y.,Buchanan, S.,Mochalkin, I.,Huber, L.,Kays, L.,Donoho, G.P.,Walgren, J.,McCann, D.,Patel, P.,Conti, I.,Plowman, G.D.,Starling, J.J.,Flynn, D.L.; Inhibition of RAF Isoforms and Active Dimers by LY3009120 Leads to Anti-tumor Activities in RAS or BRAF Mutant Cancers.; Cancer Cell, 28:384-398, 2015; PubMed: 26343583; DOI: 10.1016/j.ccell.2015.08.002

実験手法

X-RAY DIFFRACTION (2.7 Å)