5C8T
Crystal structure of the SARS coronavirus nsp14-nsp10 complex with functional ligand SAM
Summary for 5C8T
Entry DOI | 10.2210/pdb5c8t/pdb |
Related | 5C8S 5C8U |
Descriptor | Non-structural protein 10, Guanine-N7 methyltransferase, ZINC ION, ... (5 entities in total) |
Functional Keywords | nsp14, nsp10, exoribonuclease, methyltransferase, transferase |
Biological source | Human SARS coronavirus (SARS-CoV) More |
Cellular location | Papain-like proteinase: Host membrane; Multi-pass membrane protein. Non-structural protein 4: Host membrane; Multi-pass membrane protein. Non-structural protein 6: Host membrane ; Multi-pass membrane protein . Non-structural protein 7: Host cytoplasm, host perinuclear region . Non-structural protein 8: Host cytoplasm, host perinuclear region . Non-structural protein 9: Host cytoplasm, host perinuclear region . Non-structural protein 10: Host cytoplasm, host perinuclear region . Helicase: Host endoplasmic reticulum-Golgi intermediate compartment . Uridylate-specific endoribonuclease: Host cytoplasm, host perinuclear region : P0C6X7 P0C6X7 |
Total number of polymer chains | 4 |
Total formula weight | 152233.66 |
Authors | Ma, Y.Y.,Wu, L.J.,Zhang, R.G.,Rao, Z.H. (deposition date: 2015-06-26, release date: 2015-07-15, Last modification date: 2015-08-12) |
Primary citation | Ma, Y.Y.,Wu, L.J.,Shaw, N.,Gao, Y.,Wang, J.,Sun, Y.N.,Lou, Z.Y.,Yan, L.M.,Zhang, R.G.,Rao, Z.H. Structural basis and functional analysis of the SARS coronavirus nsp14-nsp10 complex Proc.Natl.Acad.Sci.USA, 112:9436-9441, 2015 Cited by PubMed: 26159422DOI: 10.1073/pnas.1508686112 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (3.2 Å) |
Structure validation
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