5C8T

Crystal structure of the SARS coronavirus nsp14-nsp10 complex with functional ligand SAM

Summary for 5C8T

• Entry DOI: 10.2210/pdb5c8t/pdb
• Related: 5C8S 5C8U
• Descriptor: Non-structural protein 10, Guanine-N7 methyltransferase, ZINC ION, ... (5 entities in total)
• Functional Keywords: nsp14, nsp10, exoribonuclease, methyltransferase, transferase
• Biological source: Human SARS coronavirus (SARS-CoV); More
• Cellular location: Papain-like proteinase: Host membrane; Multi-pass membrane protein. Non-structural protein 4: Host membrane; Multi-pass membrane protein. Non-structural protein 6: Host membrane ; Multi-pass membrane protein . Non-structural protein 7: Host cytoplasm, host perinuclear region . Non-structural protein 8: Host cytoplasm, host perinuclear region . Non-structural protein 9: Host cytoplasm, host perinuclear region . Non-structural protein 10: Host cytoplasm, host perinuclear region . Helicase: Host endoplasmic reticulum-Golgi intermediate compartment . Uridylate-specific endoribonuclease: Host cytoplasm, host perinuclear region : P0C6X7 P0C6X7
• Total number of polymer chains: 4
• Total formula weight: 152233.66

Authors

Ma, Y.Y.,Wu, L.J.,Zhang, R.G.,Rao, Z.H. (deposition date: 2015-06-26, release date: 2015-07-15, Last modification date: 2015-08-12)

• Primary citation: Ma, Y.Y.,Wu, L.J.,Shaw, N.,Gao, Y.,Wang, J.,Sun, Y.N.,Lou, Z.Y.,Yan, L.M.,Zhang, R.G.,Rao, Z.H.; Structural basis and functional analysis of the SARS coronavirus nsp14-nsp10 complex; Proc.Natl.Acad.Sci.USA, 112:9436-9441, 2015; PubMed: 26159422; DOI: 10.1073/pnas.1508686112

Experimental method

X-RAY DIFFRACTION (3.2 Å)